The effect of systemic therapies on hemogram parameters and C-reactive protein in patients with psoriatic arthritis
Background: Some inflammatory parameters were evaluated and found to be higher in psoriatic arthritis (PsA) patients compared to controls. The aim of this study is to investigate the changes in hemogram parameters and C-reactive protein (CRP) in PsA patients receiving systemic therapies. Methods: In this retrospective study, hemogram parameters, CRP and systemic inflammation indices [neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio, systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI)] of 50 PsA patients were analyzed before and in the third month of the treatments. Results: Mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and hemoglobin (Hb) were higher in the third month of all treatments compared to the baseline (p=0.009, 0.003, and 0.036, respectively). Platelet, CRP and SII were lower (p= 0.001, 0.000, and 0.000, respectively). In the biological therapy group (n=21), platelet, SIRI, and SII were lower, while MCHC was higher in the third month than baseline (p= 0.023, 0.033, 0.000, and 0.003, respectively). CRP and SII were lower in the third month of the non-biologic treatment group (n=29) compared to the baseline, and MCH and mean corpuscular volume (MCV) were higher (p= 0.001, 0.000, 0.027, and 0.044, respectively). No statistically different changes were recorded in NLR, PLR, and other parameters. Conclusion: Hb, MCH, and MCHC increased and platelet, CRP, and SII decreased with all systemic therapies. MCV was higher in the non-biologic treatment group, and SIRI was lower in the biological treatment group. Therefore, these parameters may be useful for monitoring the effects of treatments in PsA.