Early-life glucocorticoids accelerate lymphocyte count senescence in roe deer

Description

The current dataset has been obtained from a longitudinal survey as part of a Capture-Mark-Recapture program taking place in two french wild roe deer (<i>Capreolus capreolus</i>) populations since almost 50 years. We used these longitudinal data to test whether higher baseline GC levels measured within the first year of life were associated with a more pronounced immunosenescence and parasite susceptibility. We first assessed immunosenescence trajectories in these populations facing contrasting environmental conditions. Then, we found that juvenile GC levels can modulate lymphocyte trajectory. Lymphocyte depletion was accelerated late in life when FGMs were elevated early in life. Although the exact mechanism remains to be elucidated it could involve a role of GCs on thymic characteristics. In addition, elevated GC levels in juveniles were associated with a higher abundance of lung parasites during adulthood for individuals born during bad years, suggesting short-term negative effects of GCs on juvenile immunity, having in turn long-lasting consequences on adult parasite load, depending on juvenile environmental conditions. These findings offer promising research directions in assessing the carry-over consequences of GCs on life-history traits in the wild.

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