A Comparative NMR-based Metabolomics Study of Lung Parenchyma of Severe COVID‑19 Patients

Published: 7 August 2023| Version 1 | DOI: 10.17632/bg45mx8rxd.1
Contributors:
Joaquin Hurtado, Andres Lopez, Jose Izquierdo, Fernando Rodriguez, Guillermo Moyna, Gonzalo Greif, Nicolas Nin

Description

COVID-19 was the most significant infectious-agent-related cause of death in the 2020-2021 period. While the upper respiratory tract and lungs are the principal sites of infection and injury, most studies on the metabolic signatures in COVID-19 patients have been carried out on serum and plasma samples. In this report we attempt to characterize the metabolome of lung parenchyma extracts from fatal COVID-19 cases and compare them with that from other respiratory diseases. Our findings provides additional insights into the pathophysiology of COVID-19 that could lead to the development of targeted therapies for the treatment of severe cases of the disease, and further highlight the potential of metabolomic approaches in COVID-19 research.

Files

Steps to reproduce

Open with Matlab or Excel (transpose columns)

Institutions

Institut Pasteur, Instituto de Salud Carlos III, Universidad Complutense de Madrid, Universidad de la Republica Uruguay

Categories

Nuclear Magnetic Resonance, Metabolomics, Lung, COVID-19

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