NK3R in the Lateral Habenula Alleviates Pain and Anxiety Comorbidity in Mice

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Figure 1. Activation of LHb neurons after pT-ION and chemogenetic activation of bilateral LHb neurons both induced orofacial allodynia and anxiety-like behaviors in mice. Figure 2. Bilateral senktide injection into the LHb reversed pT-ION-induced allodynia and anxiety-like behaviors by suppressing the excitability of neurons. Figure 3. Bilateral SB222200 injection into the LHb induced allodynia and anxiety-like behaviors in WT mice by activating neurons. Figure 4. fPAG is one of endogenous sources of NKB in the LHb. Figure 5. Chemogenetic inhibition of the release of NKB in the fPAG reverses the alleviating effect of Tacr3 overexpression in the LHb on pT-ION-induced allodynia and anxiety-like behaviors.

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