Basic Cohort Study: Dapsone is an anticatalysis for Alzheimer’s disease exacerbation

Published: 7 April 2022| Version 2 | DOI: 10.17632/bt6h5trpg9.2
Jong-hoon Lee


There were a total of 451 ICD codes in Sorokdo National Hospital. Therefore, a total of 7603 ICD code persons from 2005 to 2020, when computerization was performed, were the study cohort of Sorok Island. Participants were randomized in a 2:1 ratio to DDS (+) or matching placebo DDS (-). Randomization was unrestricted (no blocking or stratification), and we analysed the ICD codes in databases of Sorokdo National Hospital. A 2:1 allocation ratio was performed because of HD patients taking dapsone for a lifetime. Therefore, it increases participants' probability of receiving the active study drug without compromising statistical power. Furthermore, the 2:1 allocation ratio led to a 10% increase in the overall sample size relative to a 1:1 allocation ratio.



Seoul National University College of Medicine


Epidemiology of Alzheimer's Disease