White matter plasticity in healthy older adults: the effects of aerobic exercise

Published: 17-02-2021| Version 1 | DOI: 10.17632/c7s4n48kd2.1
Contributor:
Andrea Mendez

Description

Here, we report the effects of a 6-month aerobic walking and dance interventions (clinical trial NCT01472744) on white matter integrity in healthy older adults (n=180, 60–79 years) measured by change in the ratio of calibrated T1- to T2-weighted images (T1w/T2w). This dataset contains: demographic variables, cognitive variables from the Virginia Cognitive Aging Battery and T1w/T2w data for each white matter region of interest. The cognitive variables include the raw scores pre and post intervention, z-scores pre and post intervention and cognitive composites. The T1w/T2w data includes T1w/T2w intensity values for each white matter region of interest, including the raw winsorized variables for pre and post intervention and the change in T1w/T2w scores. We calculated the 6-month change scores in the variables of interest as the post-intervention z-score minus pre-intervention z-score. We also include the R code to replicate the linear mixed effect models observed in our study: "White matter plasticity in healthy older adults: the effects of aerobic exercise". The data is from the FAST randomized controlled trial. ClinicalTrials.gov Identifier: NCT01472744.

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Steps to reproduce

Please refer to https://doi.org/10.1101/2020.11.09.20228627 for more information (see Methods).