Prevalence and Risk Factors for Hospitalization from Non-Cutaneous Infections in Patients with Hidradenitis Suppurativa _ Supplementary material
Description
Background: Adults with Hidradenitis suppurativa (HS) have comorbidities and are subjected to treatments that may increase their risk for serious infections. Objectives: Estimate the prevalence and risk factors for non-cutaneous infections (NCI) related hospitalizations in adults with HS and analyze their patterns of healthcare utilization. Methods: This retrospective cohort included dermatologist-confirmed HS patients from a single healthcare system from 2018 to 2022. Primary/secondary diagnostic codes identified NCI-related hospitalizations. Multivariable logistic regression assessed risk factors. Non-psychiatric hospitalizations and emergency department (ED) visits were collected for overall healthcare utilization. Results: Among 834 HS patients, 6,4% were hospitalized for NCI during the study period. The most common infections were urinary tract infections (18.8%), musculoskeletal infections (13%), and Covid-19 (11.7%). The main factors associated with NCI were public insurance (OR:2.05; CI:1.08 – 3.76), chronic kidney disease (OR:6.42; CI:1.68 – 24.21), and anxiety (OR:3.13; CI:1.63-5.93). Non-psychiatric hospitalization prevalence was 24.6%, and ED visits were 45.3%. Limitations: Limited generalizability due to a single health system. Conclusions: Patients with HS have a significant prevalence of hospitalizations from NCI, with UTIs being the most prevalent. The risk was higher in those with anxiety or chronic kidney disease. Future research should focus on interventions and preventive measures to prevent infection.