Supplemental Data: Systemic immune profiling identifies elevated MRGPRX2 with a distinct inflammatory signature in chronic pruritus of unknown origin

Published: 21 July 2025| Version 2 | DOI: 10.17632/c859f6y5bc.2
Contributors:
Yagiz Matthew Akiska, Aaron Bao, Davies Gage, Shahin Shahsavari, Selina Yossef, Louis Born, Kavita Vats, Madan Kwatra, Shawn Kwatra

Description

Supplemental Figure 1 – Serum IgE and MRGPRX2 Levels Boxplots comparing serum IgE and MRGPRX2 concentrations among Chronic Pruritus of Unknown Origin (CPUO), Atopic Dermatitis (AD), and Healthy Controls (HC). Demonstrates elevated MRGPRX2 in CPUO and elevated IgE in AD. Statistical comparisons included. Supplemental Figure 2 – Correlation of MRGPRX2 with SCF and Eotaxin Scatter plots showing Pearson correlations between MRGPRX2 expression and SCF (stem cell factor) and eotaxin levels in CPUO patients. Includes confidence intervals and linear regression lines. Supplemental Table 1 – Age-Adjusted Regression Analysis Linear regression models evaluating the association between age and immune biomarkers (MRGPRX2 and IgE) in CPUO and AD groups. Includes regression coefficients, confidence intervals, p-values, and R².

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Institutions

  • University of Maryland School of Medicine

Categories

Dermatology, Atopic Dermatitis, Translational Medicine, Pruritus, Precision Medicine

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