Studies on the water-promoted synthesis of chalcones. A contribution to the green synthesis of organic compounds

Description

Supporting information. Herein, a methodology for the water-promoted synthesis of chalcones is presented, a green methodology, that pretends adding to the new ecologic tendencies and showing the capabilities and limitations of water to promoting the synthesis of organic molecules. Reaction proceeds at room temperature using only KOH (a green base and shown a broad applicability, since 38 derivatives were prepared in good to excellent yields (up to 98%). In addition, most compounds were recovered pure enough by simply filtration and water washing.

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Melting points were determined on a Fisher-Jones apparatus and are uncorrected. 1H-NMR and DEPTQ spectra were recorded at 25°C on a Bruker Ascend™ 600 MHz (1H NMR and 150 MHZ DEPTQ). Chemical shifts are expressed as δ (ppm) values relative to TMS as internal standard, coupling constants (J) values are given in Hertz, most spectra were recorded in CDCl3. Multiplicities are described as s (singlet), d (doublet), dd (doublet double), dt (triplet double), t (triplet), q (quartet), or m (multiplet). All reagents were acquired from Sigma-Aldrich. The chromatography solvents were technical grade, and they were purified and distilled before being used.

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