Clinical outcomes of high-risk cutaneous squamous cell carcinomas treated with Mohs micrographic surgery alone: an analysis of local recurrence, regional nodal metastases, progression-free survival, and disease.

Published: 21 June 2022| Version 1 | DOI: 10.17632/cc97k3pftw.1
Contributors:
Teo Soleymani,
David Brodland,
Julia Arzeno,
Danny Sharon,
John Zitelli

Description

Clinical outcomes of high-risk cutaneous squamous cell carcinomas treated with Mohs micrographic surgery alone: an analysis of local recurrence, regional nodal metastases, progression-free survival, and disease. Supplemental Table 1 Patient demographics and high-risk tumor characteristics Supplemental Table 2 Multivariate Cox regression analysis demonstrating hazard ratios for high-risk tumor characteristics and associations with poor clinical outcomes. Statistically significant findings are highlighted in yellow. Supplemental Table 3 High-risk features associated with poor outcomes are presented as multivariate Cox proportional hazards models. Tumor features correlating with poor outcomes included size > 2cm, poor differentiation, and perineural invasion. Importantly, multivariate analysis demonstrated that poor differentiation was statistically significant for an increased risk of all poor outcomes – LR, NM, DM, and DSD. Supplemental Table 4 10-year cumulative incidence comparisons of local recurrence, nodal metastases and disease-specific death for high risk cSCC, stratified by AJCC and BWH stages, with our cohort compared to standardized historic published controls

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Categories

Dermatology, Mohs Surgery, Squamous Cell Carcinoma

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