Datasets Comparison
Version 1
HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease
Description
Human DLE demonstrates expression of HIF1- and cytotoxic molecules including granzyme B in the DLE lymphocytic infiltrate. Normalized gene expression per region of interest (ROI) in DLE or normal control skin (n = 3 patients, 3 ROIs per patient) as characterized by Nanostring GeoMx Digital Spatial Profiling. ROIs were selected to include T cell rich infiltrate. Cancer Transcriptome Atlas RNA probe set used.
Institutions
Yale University School of Medicine
Categories
Skin, Lupus Erythematosus
Licence
Creative Commons Attribution 4.0 International
Version 2
HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease
Description
Human DLE demonstrates expression of HIF1- and cytotoxic molecules including granzyme B in the DLE lymphocytic infiltrate. Normalized gene expression per region of interest (ROI) in DLE or normal control skin (n = 3 patients, 3 ROIs per patient) as characterized by Nanostring GeoMx Digital Spatial Profiling. ROIs were selected to include T cell rich infiltrate. Cancer Transcriptome Atlas RNA probe set used.
Institutions
Yale University School of Medicine
Categories
Skin, Lupus Erythematosus
Licence
Creative Commons Attribution 4.0 International