Comparative data on aggressive biting behavior in mice of ddY strain measured by two independent devices

Description

The Aggressive Response Meter (ARM) has been validated for measuring emotional aggression triggered by mental irritation in mice (Kuchiiwa and Kuchiiwa J. Neurosci. Methods, 2014; Kuchiiwa and Kuchiiwa J. Neurosci. Methods, 2016). It is used for revealing aggressive behavior of stressed animals and/or for investigating the effect of psychiatric drugs on aggression (Furukawa et al., Biochem. Biophys. Res. Com., 2017; Igarashi et al., Brain Res., 2021). We present data on whether the newly developed apparatus (PowerLab compatible-type ARM; pARM) is also valid to evaluate emotional (psychotic) aggressive biting behavior (ABB) of mice as the prior device (the ARM; Muromachi Kikai Co., Ltd.) has been. Mice (ddY strain) were singly-housed from 3 until 11 weeks after birth. In the experiment #1, a set of mice (10 males and 10 females) were measured with the pARM, then with the ARM at 9 weeks after birth. In the experiment #2, another set of mice (10 males and 10 females) were measured with the ARM, then with the p-ARM at 10 weeks after birth. In brief, these devices semi-automatically measured the average intensity and total number of bites in one 5-min session, which consisted of 30 presentations of two metal rods in front of each mouse, after an “irritation session” in which the hind paw of the mouse was stimulated 30 times in a 5-min session. The average intensity of one bite and the total number of bites within 30 presentations of metal rods in front of each mouse were recorded as ABB intensity and ABB frequency, respectively. Raw data from individual mice on ABB intensity and frequency (Table 1) is presented.

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