Juxtaposition of IL-1β and IFN-γ expression and apoptosis of keratinocytes in adult-onset still’s disease

Published: 10 July 2019| Version 1 | DOI: 10.17632/csp4939d3j.1
Contributors:
,
, Haijing Wu, Ming Zhao,
,
,
, Lixia Lu,
, Qianjin Lu

Description

The unique pathological manifestation was presented in all APSEs patients but could hardly be found in ESEs patients. Besides CD11b+ and CD68+ cells, there were more CD4+ T-cells infiltrate in the dermis of APSEs than in ESEs. IL-1β and IFN-γ were specifically expressed in the upper third of the epidermis, juxtaposition to the loci of the necrotic keratinocytes.

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Immunology, Dermatology, Pathology

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