Juxtaposition of IL-1β and IFN-γ expression and apoptosis of keratinocytes in adult-onset still’s disease

Published: 10 July 2019| Version 1 | DOI: 10.17632/csp4939d3j.1
Contributors:
Shijia Rao,
Qianwen Li,
Haijing Wu,
Ming Zhao,
Alun Wang,
Guiying Zhang,
Ji Li,
Lixia Lu,
Wei Shi,
QIANJIN LU

Description

The unique pathological manifestation was presented in all APSEs patients but could hardly be found in ESEs patients. Besides CD11b+ and CD68+ cells, there were more CD4+ T-cells infiltrate in the dermis of APSEs than in ESEs. IL-1β and IFN-γ were specifically expressed in the upper third of the epidermis, juxtaposition to the loci of the necrotic keratinocytes.

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