Behavioral data and statistical summary tables for “Cocaine disrupts stress resilience through state-dependent dopaminergic mechanisms in the nucleus accumbens”
Description
This dataset contains processed behavioral data and statistical summary tables supporting Figures 1–4 of the manuscript “Cocaine disrupts stress resilience through state-dependent dopaminergic mechanisms in the nucleus accumbens.” The data include social interaction tests, cocaine-conditioned place preference, conspecific interaction, elevated plus maze, forced swim test, and chemogenetic manipulation of TH-positive NAc-projecting neurons. Raw video files are not included. Statistical analyses were performed using SigmaPlot version 16.
Files
Steps to reproduce
The dataset contains processed behavioral data and statistical summary tables supporting Figures 1–4 of the associated manuscript. Raw video files are not included. To reproduce the reported analyses, open each figure-level CSV file and use the variables defined in data_dictionary.csv. Primary statistical analyses were performed using SigmaPlot version 16. The primary results are summarized in statistics_summary.csv. Normality and equal-variance checks are summarized in assumption_checks.csv. Non-parametric sensitivity analyses for comparisons with assumption violations are summarized in nonparametric_sensitivity.csv. For Figures 1 and 2, social interaction data are provided in long format with target_status indicating no-target or target phases. For Figure 3, behavioral values are provided as post/pre ratios. For Figure 4, raw long-format behavioral values and target-minus-no-target subtraction scores are provided separately. Figure 1 baseline social interaction data before cocaine exposure were derived from a subset of animals included in Ohnishi et al., Neuroscience, 2015. The dataset does not reproduce the full previously published cohort; it contains only the subset of animals that subsequently underwent cocaine exposure and was analyzed in the present manuscript. Post-cocaine behavioral measurements are newly reported in the present study.
Institutions
- Kurume UniversityFukuoka, Kurume
Categories
Funders
- Ishibashi FoundationTokyo, Tokyo
- National Institute on Drug AbuseMaryland, Bethesda