Data set for Prelimbic cortical stimulation improves spatial memory through distinct patterns of hippocampal gene expression in aged rats

Published: 4 April 2020| Version 1 | DOI: 10.17632/d5xc8ns3vg.1
Shawn Zheng Kai Tan, Lee Wei Lim


Dementia poses major health challenges worldwide, yet current treatments are faced with issues of efficacy and toxicity. Deep Brain Stimulation (DBS) is a promising non-pharmacological treatment for dementia, but most DBS studies have used young healthy animals, which may not be aetiologically relevant. In this study, we focused on an aged rat model in which cognitive decline occurs through a natural ageing process. We used a Morris Water Maze to determine the effects of prelimbic cortex (PrL) DBS on memory. For underlying mechanisms of DBS effects, we then carried out microarray. We showed that DBS of the prelimbic cortex (PrL) improved performance in the Morris Water Maze and is related to distinct patterns of changed gene expression, with G-protein-coupled receptor pathways playing a central role. Our results suggest that non-neurogenesis pathways play a role in the effects of DBS. Further studies are needed to investigate the effects of DBS on memory beyond neurogenesis and consider the highlighted pathways suggested by our data.



Neuromodulation, Dementia, Microarray