FEOBV and auditory training

Published: 16 Jul 2019 | Version 1 | DOI: 10.17632/ddm47dxms7.1

Description of this data

The cholinergic system functions as a gating mechanism that enhances attention and thus regulates adult neuroplasticity. Aging, however, is associated with a progressive degeneration of the cholinergic system that impairs the acquisition of skills acquired through learning or during functional recovery following neurological injury. Although cognitive training and perceptual learning have been shown to enhance auditory cortical processing, their specific impact on the cholinergic system remains unknown. Here we used [18F]-FEOBV, a positron-emission tomography (PET) radioligand that selectively binds to the vesicular acetylcholine transporter (VAChT), as a proxy to assess whether training on a perceptual task results in increased cholinergic neurotransmission. We show, for the first time, that perceptual learning is associated with region-specific changes in cholinergic neurotransmission detected by [18F]-FEOBV PET imaging, and corroborated with immunohistochemistry.

Experiment data files

Latest version

  • Version 1

    2019-07-16

    Published: 2019-07-16

    DOI: 10.17632/ddm47dxms7.1

    Cite this dataset

    Cisneros-Franco, J. Miguel (2019), “FEOBV and auditory training”, Mendeley Data, v1 http://dx.doi.org/10.17632/ddm47dxms7.1

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Categories

Acetylcholine, Plasticity, Auditory Cortex, Animal Training, Perceptual Learning

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The files associated with this dataset are licensed under a Creative Commons Attribution 4.0 International licence.

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This dataset is licensed under a Creative Commons Attribution 4.0 International licence. What does this mean? You can share, copy and modify this dataset so long as you give appropriate credit, provide a link to the CC BY license, and indicate if changes were made, but you may not do so in a way that suggests the rights holder has endorsed you or your use of the dataset. Note that further permission may be required for any content within the dataset that is identified as belonging to a third party.

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