Fractional ablative CO2 laser treatment for acne scars in patients receiving isotretinoin. A randomized controlled split-face comparison trial
Description
We evaluate the safety and efficacy of fractional ablative CO2 laser (FACL) in patients treated concomitantly with ITN. We conducted a split-face comparison trial in 21 patients treated with ITN. The randomized half-face received three monthly sessions of FACL. Final cosmesis was scored using the Quantitative Global Acne Scarring Grading System (GASGS), by 3 independent dermatologists. Self-evaluation of cosmetic results were measured using a questionnaire. Adverse effects were recorded after each laser session and one year after the end of the treatment. There were no unexpected adverse events throughout the study. The GASGS of the FACL treated side of the face was significantly lower than the untreated side (4.71 ± 2.56 vs. 9.79 ± 3.5, respectively, P < 0.001), an improvement of 51.8%. Patient-scored overall improvement were significantly higher on the FACL-treated side (2.81±0.75 vs. 1.57±0.97, P < 0.001). Concomitant treatment of FACL in patients receiving ITN is safe. Efficacy of the dual regimen was superior to ITN treatment alone.