Polymeric mesoporous carrier for drug delivery
Polymeric mesoporous carrier from cellulose acetate butyrate was loaded with Felodipine and molecular interactions between the drug and internal mesopore surface explored. The findings reveal that a ‘surface anchoring’ effect could be responsible for the lack of crystal-like ordered structure of the drug within mesopores. The more soluble amorphous form was preserved inside the carrier’s mesopores, despite its known poor glass forming ability, which translated into enhanced dissolution and relative bioavailability.
Steps to reproduce
-Drug loading to polymeric mesoporous carriers -Characterisation by various analytical techniques such as DSC, TEM & SEM, porosimetry, HPLC -Molecular dynamics simulation -In vivo study