Nasal Carriage of Methicillin Resistant Staphylococcus aureus in Children Living with HIV Attending Infectious Diseases Clinics in Kano

Published: 8 October 2021| Version 1 | DOI: 10.17632/dmw9vfgyng.1
Contributors:
Aisha Habib Sadauki,
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Description

This dataset contains socio-demographic and clinical characteristics of Children Living With HIV (CLWH), their nasal S. aureus carriage status, antimicrobial susceptibility of S. aureus isolates obtained from the children and presence of the mecA gene in S. aureus isolates. We estimated the nasal colonization with S. aureus and MRSA in CLWH in Kano State, Nigeria and determined associated factors through a cross-sectional study in the infectious diseases’ clinics of two public hospitals in Kano involving 214 CLWH/caregiver pairs. We selected children from clinic registers by simple random sampling. We used an interviewer-administered questionnaire to elicit factors associated with MRSA carriage from the caregivers. Clinical records were reviewed for patients’ medical history. We used standard antimicrobial techniques to isolate S. aureus from nasal swabs taken from CLWH. MRSA was detected using the cefoxitin disc diffusion method and simple PCR for mecA gene detection. We estimated the prevalence of S. aureus and MRSA carriage in the CLWH and calculated adjusted odds ratios (aOR) for factors associated with MRSA. Nasal S. aureus carriage in the CLWH was 18.7% (40/214). Cefoxitin disc diffusion revealed 6/214 (2.8%) of CLWH were MRSA carriers, while simple PCR revealed that 9/214 (4.2%) of CLWH were MRSA carriers. Recent hospitalization (aOR: 61.04; 95% CI: 9.01-413.38)) and recent antibiotic therapy (aOR: 7.52; 95% CI: 1.07-52.95) were independent risk factors for MRSA colonization. There was MRSA nasal colonization among CLWH in Kano. The hospitals’ Infection Prevention and Control units should institute measures and educate CLWH and their caregivers to reduce MRSA spread.

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Categories

Pediatrics, HIV/AIDS, Methicillin-Resistant Staphylococcus aureus

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