Thiol-Disulphide Homoeostasis in Covıd-19: Evaluation of its Relationship with Complete Blood Count Parameters

Published: 29-12-2020| Version 1 | DOI: 10.17632/dtrjfdgnv6.1
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This study was conducted with 68 individuals who applied to Sakarya University Medical Faculty Training and Research Hospital between May 15 and August 15 with positive COVID-19 PCR results, which were treated and followed up in the service and intensive care unit (ICU), as well as any chronic diseases and drugs admitted to the general internal medicine outpatient clinic on the same dates as a control group with negative PCR test results. Individuals with positive COVID-19 PCR results were divided into two groups as inpatients (33) and ICU (35) patients. Within the scope of the study, the patients' age, gender, chronic diseases and clinical information (application complaints, hospitalization in the medical floor-ICU, intubation status, death or discharge status and the drugs they used) were obtained through the hospital automation system. Patients who refused to participate in the study and were under 18 years of age were excluded from the study. Remaining parts of the samples taken during routine analysis were kept under appropriate conditions and no additonal sample was taken. All values obtained were evaluated in the SPSS (ver. 20.0; SPSS, USA) program. The mean, median, min-max value and standard deviations of the measurement results were calculated. The Shapiro-Wilk Test was used to determine whether the data conformed to normal distribution. Student-t test was used when parametric test conditions were met in groups with two independent variables, Mann-Whitney U test if not provided, One-Way Analysis of Variance if parametric test conditions were met in groups with more than two independent variables, and Kruskal-Wallis test if not. Pearson Chi-Square test was used for categorical variables. Correlation and analysis were performed to evaluate the relationship between thiol-disulfide levels of patients with CBC parameters and clinical course. Significance was assessed at least at the p <0.05 level. In addition, the relationship between TT, NT, DD, lymphocyte, neutrophil, WBC, PLR, NLR parameters and the need for intensive care treatment (prognosis) of the patients was also examined by ROC analysis.