Urinary Paraben Concentrations and Its Association with Serum Triglyceride Concentrations in 2013-2014 NHANES Participants: A Cross-Sectional Study

Published: 21 October 2020| Version 1 | DOI: 10.17632/f6d7pr8tf6.1
Contributor:
Rebecca Pazos

Description

Background: Alkyl esters of para-hydroxybenzoic acid, colloquially known as parabens, are types of preservatives found in multiple foodstuffs, pharmaceuticals and personal care products to which Americans are exposed daily. It is unclear if parabens exhibit endocrine-disrupting properties. Parabens may interact with triglycerides in adipose tissue and impact lipid metabolism. Objective: To evaluate the association between urinary parabens concentrations and serum triglyceride concentrations. Design: A cross-sectional study. Setting: The Mobile Examination Centers affiliated with 2013-2014 NHANES. Participant(s): 827 adults (20 years or older) affiliated with the 2013-2014 NHANES. Intervention(s): None. Main Outcome Measure(s): Triglyceride levels were associated with urinary paraben concentrations (methyl, ethyl and propyl) using a hierarchical multiple regression, adjusting for ethnicity/race, gender, BMI and age. Unadjusted results are also reported. Results: The geometric mean of the urinary concentration of methylparaben, ethylparaben and propylparaben were 57.100, 2.537, and 6.537 ng/ml respectively. Triglycerides concentrations were inversely associated with methylparaben (β = - 0.092, P=.007), ethylparaben, (β = - 0.066, P=.045), and propylparaben (β = - 0.076, P=.025).When adjusting for age, gender, race/ethnicity, and BMI , the model remained significant for methylparaben R2 = 0.125, ethylparaben R2 = 0.122, and propylparaben R2 = 0.123, suggesting each paraben makes a unique contribution to the model. Being female, Non-Hispanic White, and Non-Hispanic Black were associated with decreasing triglyceride levels in the presence of methylparaben, ethylparaben and propylparaben and age, BMI and being male were associated with increasing circulating triglycerides. Conclusion: Despite the potential detrimental effects of parabens on triglycerides, our results suggest that urinary excretions of methylparaben, ethylparaben and propylparaben are associated with lower concentrations of circulating triglycerides in certain populations. Further research is needed to confirm the mechanisms and health impact of this relationship. Keywords: methylparaben, ethylparaben, propylparaben, triglycerides, lipid metabolism

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Health Promotion in Environmental Health

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