Utility of Global Registry of Acute Coronary Event Score (GRACE) and Thrombolysis in Myocardial Infarction Risk Score (TIMI Score) in Predicting 30-day Mortality in Patients undergoing Primary Angioplasty in a Tertiary care centre
Description
The research title entitled " Utility of Global Registry of Acute Coronary Event Score (GRACE) and Thrombolysis in Myocardial Infarction Risk Score (TIMI Score) in Predicting 30-day Mortality in Patients undergoing Primary Angioplasty in a Tertiary care centre – A record-based study" aims to assess the effectiveness of GRACE and TIMI risk scores in predicting outcomes for patients who underwent primary Percutaneous Coronary Intervention at a tertiary care centre. The study enrolls 87 patients who underwent primary PCI after a diagnosis of ST-elevation myocardial infarction and information was extracted from the medical records, encompassing the computation and documentation of both GRACE and TIMI scores. ROC curve analysis was conducted, subsequently yielding the area under the curve alongside a 95% confidence interval, which was duly reported. The study underscores the comparable discriminatory capacities of both TIMI and GRACE scores in predicting 30-day mortality among patients afflicted with STEMI. With the TIMI Risk Score, which has a sensitivity of 85% and specificity of 99%, supported by a p-value of 0.008, and the GRACE Score, which indicates a sensitivity of 85% and specificity of 99%, along with a p-value of 0.006, the prognostic performance of these scoring methods demonstrated a strong similarity. The sensitivity and specificity metrics were acquired through meticulous analysis of the receiver operating characteristic curve. The TIMI Risk Score exhibited a sensitivity of 85% and specificity of 99%, whereas the GRACE Score demonstrated a sensitivity of 85% and specificity of 99%, which were utilized to predict 30-day mortality among patients with STEMI and after one month of observation, there was an observable enhancement in left ventricular function. The study concludes that the recuperation of left ventricular function following primary PCI is characterized by a gradual improvement over time, rather than an immediate and pronounced recovery.