PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD through suppressing eEF2 phosphorylation. Shen et al.

Published: 22 February 2021| Version 1 | DOI: 10.17632/fks2k9hhmc.1
Contributors:
Yuqian Shen,
Zi Chao Zhang,
Shanshan Cheng,
An Liu,
Jian Zuo,
Shuting Xia,
Xian Liu,
Wenhua Liu,
Zhengping Jia,
Wei Xie,
Junhai Han

Description

Translation elongation controls the efficiency and accuracy of protein synthesis. Shen et al. discover that the intellectual disability-associated protein PQBP1 regulates translation elongation through direct interaction with eEF2, protecting it from phosphorylation. Loss of PQBP1 in the hippocampal neurons impairs metabotric glutamate receptor-induced long term depression and associated behaviors.

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Institutions

Southeast University

Categories

Neuroscience, Cell Biology, Synaptic Plasticity, Protein Synthesis, Mental Retardation, Learning and Memory

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