PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD through suppressing eEF2 phosphorylation. Shen et al.
Translation elongation controls the efficiency and accuracy of protein synthesis. Shen et al. discover that the intellectual disability-associated protein PQBP1 regulates translation elongation through direct interaction with eEF2, protecting it from phosphorylation. Loss of PQBP1 in the hippocampal neurons impairs metabotric glutamate receptor-induced long term depression and associated behaviors.