A novel L-shaped ortho-quinone analog suppresses glioblastoma progression by targeting acceleration of AR degradation and regulating PI3K/AKT pathway

Published: 7 May 2024| Version 1 | DOI: 10.17632/fxh32yj6tj.1
Contributor:
Xiao Hu

Description

We have added three full tables containing the two gene list of GBM DEGs and TE5 targets with the 44 common highlighted.

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The differentially expressed genes between GBM and paracancerous tissues were screened using the GEPIA 2 database (https://gepia2.cancer-pku.cn). The possible GBM targets of TE5 were predicted using the SwissTargetPrediction database (http://www.swisstargetprediction.ch). The Venny2.1 online analysis (https://bioinfogp.cnb.csic.es/tools/venny/index.html) helped obtain the intersection targets between TE5 and GBM differential genes. The crystal protein structures were obtained from the PDB protein database (https://www.rcsb.org/). The binding energies between the proteins and TE5 were determined to select a predicted docking position by using the molecular docking program Auto Dock Vina 1.2.0 software.

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Neuropharmacology

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