A novel L-shaped ortho-quinone analog suppresses glioblastoma progression by targeting acceleration of AR degradation and regulating PI3K/AKT pathway

Published: 7 May 2024| Version 1 | DOI: 10.17632/fxh32yj6tj.1
Xiao Hu


We have added three full tables containing the two gene list of GBM DEGs and TE5 targets with the 44 common highlighted.


Steps to reproduce

The differentially expressed genes between GBM and paracancerous tissues were screened using the GEPIA 2 database (https://gepia2.cancer-pku.cn). The possible GBM targets of TE5 were predicted using the SwissTargetPrediction database (http://www.swisstargetprediction.ch). The Venny2.1 online analysis (https://bioinfogp.cnb.csic.es/tools/venny/index.html) helped obtain the intersection targets between TE5 and GBM differential genes. The crystal protein structures were obtained from the PDB protein database (https://www.rcsb.org/). The binding energies between the proteins and TE5 were determined to select a predicted docking position by using the molecular docking program Auto Dock Vina 1.2.0 software.