Polymorphic markers of genes FTO, KCNJ11, CDKAL1, SLC30A8, and CDKN2B in Russian population of Type 2 Diabetes

Published: 18 December 2016| Version 2 | DOI: 10.17632/fys583ghzm.2
Alex Nikitin,
Viktor Potapov,
Olga Brovkina,
Ekaterina Koksharova,
Dmitry Khodyrev,
Yury Philippov,
Marina Michurova,
Minara Shamkhalova,
Olga Vikulova,
Svetlana Smetanina,
Lyudmila Suplotova,
Irina Kononenko,
Viktor Kalashnikov,
Olga Smirnova,
Aleksander Mayorov,
Valery Nosikov,
Alexander Averyanov,
Marina Shestakova


The datasheet contains results for SNPs screening in genes are potentially involved in impaired glucose metabolism or impaired β-cells function: rs5219 of the KCNJ11 gene, rs13266634 of the SLC30A8 gene, rs10811661 of the CDKN2B gene, and rs9465871, rs7756992, and rs10946398 of the CDKAL1 genes. Also in contains metabolic indicators of glucose intolerance and β-cell dysfunction of same patients. Data were collect within the study founded by Russian Science Foundation (grant #14-25-00181).


Steps to reproduce

Population: 862 patients diagnosed with T2DM and 443 randomly selected health resort patients showing no signs of the T2DM based on clinical and biochemical examination. SNPs screening: Real-time PCR for alleles of polymorphic markers of FTO, KCNJ11, CDKAL1, SLC30A8, and CDKN2B. Glucose metabolism evaluation: Blood glucose and insulin concentrations at baseline and 2 h after an oral glucose tolerance test (i.e. for use HOMA-IR and HOMA-β models).


Single Nucleotide Polymorphism, Insulin Resistance, Sequence Analysis