Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2. Walls, Fiala et al.

Published: 23-10-2020| Version 1 | DOI: 10.17632/g5t8cr2s3s.1
Lexi Walls,
Brooke Fiala,
David Veesler,
Neil King


Walls, Fiala et al describe a self-assembling protein nanoparticle displaying the SARS-CoV-2 receptor-binding domain in a highly immunogenic array eliciting diverse, potent and protective antibody responses. The nanoparticle vaccines induce neutralizing antibody titers ten-fold higher than the prefusion-stabilized spike ectodomain trimer using a five-fold lower dose.