Effect of CYP3A4 polymorphism on citalopram metabolism

Description

The original data file meticulously records the effects of CYP3A4 genetic polymorphisms on the metabolism of citalopram, including experimental results for CYP3A4 wild-type（CYP3A4*1） and 21 variants. Each data table presents the concentrations of the metabolite (demethylcitalopram) measured after incubating varying gradient concentrations of citalopram with CYP3A4 enzymes. This data is suitable for Michaelis-Menten kinetic analysis, enabling the calculation of relevant enzymatic kinetic parameters to assess the functional differences among the variants in citalopram metabolism.

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