Trends in Non-squamous cervical cancer incidence, histological type, stage, age, and human papillomavirus type in southwest China from 2009 to 2021: A Large Retrospective Study

Published: 5 January 2023| Version 1 | DOI: 10.17632/gmg54ngfnk.1
Liang Sun


Nowadays, with the declining incidence of squamous cell cancer, the incidence of non-squamous cervical cancer is rising in developed countries. However, little is known about non-squamous cervical cancer in China. In this study, we retrospectively analyzed the pattern of non-squamous cervical cancer (incidence, age, histological type, stage, and human papillomavirus subtype) in southwestern China between January 1, 2009 and December 31, 2021. The histological classification was conducted according to World Health Organization (WHO) 2020 tumor classification. HPV detection for paraffin-embedded tumor tissue was done by use PCR-reverse dot blot hybridization probe assay. In our study, we found that the trends of increasing non-squamous cervical cancer incidence existed in cervical cancer in the older population, and most cases were associated with HPV. The rate of HPV-independent cervical cancer was small, but the majority of patients were diagnosed at an advanced stage. In contrast to the increasing incidence trends of adenocarcinoma for young women in some western countries, our study showed an increasing age. These results call for increasing effort in screening and HPV vaccination in China.


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The study was conducted in West China Second Hospital of Sichuan University. This was a retrospective descriptive study.Patients treated with cervical cancer at the West China Second Hospital of Sichuan University from 2009 to 2021 were reviewed, and only non-squamous cervical cancer patients were included. The study included 1,928 patients with non-squamous cervical cancer between 2009 and 2021.The histological reclassification was performed according to WHO 2020 female genital tumor classification. Tumor staging was also re-evaluated according to the 2018 International Federation of Gynecology and Obstetrics staging system. Demographic and clinicopathologic features were obtained. A proportional weighting attribution method was used to combine multiple HPV infections into a single type.


Sichuan University West China Second University Hospital Department of Pathology


Epidemiological Research