Pharmaco-EEG dataset

Published: 18 September 2020| Version 1 | DOI: 10.17632/gmkbhj28jh.1
Contributor:
Konstantin Kalitin

Description

• Project name: ANN4EEG • Project home page: https://cmi.to/ann4eeg Experimental protocol Rats were randomized and administered various anticonvulsants at the maximum single therapeutic dose (conversion factor from humans to rats used in this study was 5.9 as recommended) or subconvulsive dose for substances with proconvulsant activity. After reaching the peak concentration (depending on the pharmacokinetic properties of the drug) under control of the operator, brain activity was recorded for 10 min. Substances Diazepam (6 mg/kg, po) Phenazepam (1 mg/kg, po) Chloral hydrate (100 mg/kg, ip) Pregabalin (60 mg/kg, po) Gabapentin (360 mg/kg, po) Carbamazepine (200 mg/kg, po) Eslicarbazepine (160 mg/kg, po) Corazol (pentylenetetrazole; 20 mg/kg, ip) Picrotoxin (2 mg/kg, ip) Pilocarpine (60 mg/kg, ip) Arecoline (40 mg/kg, ip) i-EEG Recording A laboratory electroencephalograph (NVX-36; MKS, Moscow, Russian Federation) was used to record bioelectrical activity. Intracranial EEG signals were recorded at a sampling rate of 500 Hz, in a bipolar montage. Electrode impedance < 5 kΩ. i-EEG montage: Olfactory bulbs (OB) (ground); P3-A1 (channel 1); O1-A1 (channel 2); P4-A2 (channel 3); O2-A2 (channel 4).

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