Modular microenvironment components reproduce vascular dynamics de novo in a multi-scale agent-based model: VASCULAR DAMAGE

Published: 15-07-2021| Version 2 | DOI: 10.17632/grtx87d27y.2
Jessica Yu


Data and results for `VASCULAR DAMAGE` simulations. Simulations of cancerous cells in colony and tissue contexts with different damage multipliers (from 0 to 1 in increments of 0.1) with relative hemodynamic fraction of 0 (static sources) or 1 (estimated hemodynamics). Each condition is run for 15 days (21600 ticks) with 10 replicates (random seeds 0 - 9). Cancerous cells (max_height x 1.5, meta_pref x 1.5, migra_threshold x 0.5) are introduced to the center of the environment after a 1 day delay. Snapshots are taken every 0.5 days (720 ticks). The data folder contains .tar.xz compressed replicate sets. The results folder contains .pkl files of data parsed into arrays. Simulations are labeled as: [context]_[damage]_[fraction] - [context] - C = colony context, cancerous cells only - CH = tissue context, cancerous cells and healthy cells - [damage] - ### = value of damage parameter (###/100) - [fraction] - ### = fraction of hemodynamic factor (###/100)


Steps to reproduce

Simulations generated using ARCADE v2.3 (available at using the following setup files: - VASCULAR_DAMAGE_C.xml - VASCULAR_DAMAGE_CH.xml All setup files are available at