A cellular taxonomy of human normal bone marrow (NBM) and AML
Published: 20 March 2024| Version 2 | DOI: 10.17632/gwjh3w6ztm.2
Contributor:
Lanpeng ChenDescription
To generate a cellular taxonomy of the human NBM and AML, representing rare HSPCs, immune cells, neoplastic cells and stromal niche populations, allowing assessment of their cellular diversity, and predicted intercellular signaling, we performed single-cell RNA sequencing (scRNA-seq) on viably frozen BM aspirates from four healthy donors and 6 AML patients with NPM1 mutation at diagnosis. Reference: A Single-Cell Taxonomy Predicts Inflammatory Niche Remodeling to Drive Tissue Failure and Outcome in Human AML; doi: 10.1158/2643-3230.BCD-23-0043.
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Institutions
Erasmus MC
Categories
Acute Myelogenous Leukemia, Bone Marrow Stromal Cell, Single-Cell RNA Sequencing