Retinal plasticity in age-related macular degeneration

Published: 6 December 2021| Version 1 | DOI: 10.17632/gx4fn84jwx.1


The goal of this particular study is to construct a realistic physical model of viscoelastic retinal stretching and, on its basis, derive a universal quantitative criterion of irreversible retinal deformations during Age-related macular degeneration (AMD). In this work, standard methods of nonlinear fracture mechanics of ductile and viscoelastic materials were applied to study the evolution of retinal deformation progress in patients with neovascular AMD in the area of large druses or subretinal or sub-RPE fluid accumulation. A two-dimensional rhombic model of viscoelastic Kelvin-Feucht primitives was used to reconstruct the parameters included in the approximation of the creep strain growth rate. A clinical case of a patient (patient X., 79 years old) was taken as a basis for theoretical research. The patient underwent retinal OCT on DRI Swept-Source OCT Triton plus (Topcon) in Radial mode (Dia. 6.0 mm Overlap 16). Transudative detachment of RPE in the macula was detected. The maximum elevation of RPE relative to the line of intact epithelium above Bruch's membrane was 868 μm. Subretinal fluid with a maximum height of neuroepithelium detachment of 134 µm was visualized at the edge of the detached RPE dome. The retinal thickness of the macular region in the zone of maximum RPE elevation was 284 μm. File 1-5 - OCT images of macula in patient with retinal pigment epithelium detachment. File 6 – the same OCT with measurements. These OCT scans were used for investigation the role of retinal plasticity in the formation of irreversible retinal deformations in age-related macular degeneration.



Volins'kij natsional'nij universitet imeni Lesi Ukrainki, Odes'ku nacional'nu mors'ku akademiu, Odes'kyj nacional'nyj medychnyj universytet


Ophthalmology, Retinal Pigment Epithelium, Age-Related Macular Degeneration, Plasticity, Mechanical Stress