Clinical features of rapid involuting congenital hemangioma: a prospective study

Published: 11 January 2024| Version 2 | DOI: 10.17632/gy893dt9ks.2
Tong Qiu, Zixin Zhang, Jiangyuan Zhou, Xue Gong, Xuepeng Zhang, Yuru Lan, Congxia Yang, Yujia Zhang, Zilong Zhou, Xian Jiang, Fan Hu, Wei Shan, Feiteng Kong, Yongbo Zhang, Qingxia Qiu, Siyuan Chen, Yi Ji


Rapid involuting congenital hemangiomas (RICHs) are rare benign tumors that occur in infancy. We conducted a prospective study to evaluate the clinical characteristics, complications, requirements for therapeutic intervention, and sequelae in patients with RICHs. Eligible patients were ≤7 days old and had RICH. The primary endpoint was the time of complete involution of RICH. Eighty-six patients were included. The involution of RICH was nonlinear. All RICH patients had signs of involution within 4 weeks of age. The time of greatest involution was between 1.3 months and 2.3 months, with a mean complete involution occurring at 10.1 months. In total, 5.8% of patients experienced complications caused by or possibly related to RICH, and only 1.2% received some form of early treatment during the study period. Severe/significant sequelae was observed in 18.6% of subjects. The location of head-face-neck was the only risk factor that predicted severe/significant sequelae (odds ratio: 4.673; 95% confidence interval: 1.326-16.667; P=0.016). RICH exhibits rapid regression within the first few months of life. Although clinical observation is recommended in patients with RICH, some lesions may leave severe/significant sequelae, especially those involving the head-face-neck area.



Sichuan University West China Hospital


Pediatrics, Hemangioma, Risk Factor (Medicine), Clinical Analysis


Sichuan Province Science and Technology Support Program

2022YFS0233 and 2022YFS0225

West China Hospital, Sichuan University

2023HXFH004, 2020HXFH048, ZYJC21060 and 2019HXFH056

National Natural Science Foundation of China


Sichuan University