Histamine and collagen regulation within the wound

Published: 18 March 2019| Version 1 | DOI: 10.17632/h632fgmzhx.1
Jacek Drobnik


Collagen accumulation in wounds is regulated by inflammatory mediators. An adequate inflammatory reaction influences deposition of that protein within granulation tissue of the wounds. The aim of the present study is to check whether histamine my influence collagen deposition acting directly on myofibroblasts derived from granulation tissue of the wound. Moreover, we plan on identifying the histamine receptor involved in this process.