Clinical Manifestations of Alopecia in Autoimmune Blistering Diseases: A Cross-sectional Study

Published: 2 September 2022| Version 1 | DOI: 10.17632/hn65fjkpzw.1
Contributors:
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Asli Bilgic Temel,
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Description

Supplementary material 1. Alopecia registration and assessment tool Supplementary material 2. The main quantitative and qualitative independent variables for data analysis and their definitions. Supplementary material 3. Clinical findings in AIBD patients with alopecia.

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A Registration and Assessment Tool (RAT) was drawn up and administered to collect demographic and clinical data (Supplementary material 1). We modified an existing alopecia evaluation form, which has been used for routine evaluation in the Hair Unit of the Department of Dermatology and Venereology, Akdeniz University, Turkey (Supplementary material 1). Specific definitions used in this study is shown in Supplementary material 2 regarding AIBD. Supplementary material 3: An AIBD Registry was utilised to approach all patients in a cross-sectional design, unless they were newly consented on the day of clinical review. Patients with a disproven original AIBD and those with neurological conditions were excluded. Participants were randomly selected new and follow-up adult patients with AIBD and consecutively recruited to minimise selection bias from a fortnightly outpatient clinic based at St George Hospital between May 2018 and September 2018. All participants gave written, informed consent according to the Declaration of Helsinki. The study was approved by the local ethics committee. A Registration and Assessment Tool (RAT) was drawn up and administered to collect demographic and clinical data (Supplementary material 1). During the visit, AIBD severity was scored using the relevant validated scoring systems (BPDAI, PDAI, EBADAI). We modified an existing alopecia evaluation form, which has been used for routine evaluation in the Hair Unit of the Department of Dermatology and Venereology, Akdeniz University, Turkey (Supplementary material 1). Specific definitions used in this study is shown in Supplementary material 2 regarding AIBD. A clinical examination, hair pull test, and trichoscopy was performed on each patient. Trichoscopic examination was performed using a polarised-light handheld dermatoscope (DermLite DL4, 3Gen LLC, San Juan Capistrano, CA), which allows scalp visualisation at a 10-fold magnification, without an interface solution. No additional invasive procedures were performed unless it was part of routine standard of care. Statistical methods Data were analysed by IBM SPSS Statistics for Mac (v19.0; IBM Corp., Armonk, NY, USA). Frequency and percentages were calculated for categorical and mean ± standard deviation for continuous variables. Both Fischer’s exact test and Mann-Whitney U test were used for categorical and continuous intergroup comparisons. Univariate and multivariate analysis were performed to evaluate the association of different variables with the severity of AIBD and alopecia. P less than 0.05 was considered statistically significant. Participants with missing data on the RAT were followed-up via phone call. 

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Akdeniz Universitesi, University of New South Wales

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Assessment

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