Data and code for "A kinetic model of continuous radiation damage to populations of cells: Comparison to the LQ model and application to molecular radiotherapy"

Published: 30 Jan 2020 | Version 1 | DOI: 10.17632/j3cy26nn8s.1
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Description of this data

Replication data for our study "A kinetic model of continuous radiation damage to populations of cells: Comparison to the LQ model and application to molecular radiotherapy".

Introduction
The folder Code_and_Data contains the following two routines (functions) and two datasets. The code is written in Matlab (.m functions), while the datasets are saved in Matlab workspace files (.mat). If any reader wants data in any other format, please contact us and we will try to accommodate her/his request.

The folder contains the following items:

annealing_model_fit.m
model_dif_radionuclide_stochastic.m
data_unkel.mat
data_iodine.mat

model_dif_radionuclide_stochastic.m
Function containing the implementation of our code. Detailed info about the inputs and outputs of this function can be found in it.

annealing_model_fit.m
Function containing the implementation of an annealing method to obtain best fits of our model to experimental data. In particular, in this case it is used to fit experimental data taken from Unkel et al of surviving fractions of different cell lines. Detailed info about the inputs and outputs of this function can be found in it.

data_unkel.mat
Workspace containing the experimental results taken from Unkel et al of surviving fractions of different cell lines, together to best-fits of such data to the LQ model and to our model.
Experimental data (doses and log(SF)) for each of the 9 cell lines is save in variables C2, DG, FP, HP, L3, MP, P1, PT, and S2, and altogether are also reported in the structure EXPERIMENTAL_DATA.
Variables named par_LQ_”cell_line” contain best-fitting LQ parameters for each cell-line, and variables SF_LQ_”cell_line” contain best-fitting LQ surviving fractions.
Variables named par_opt_”cell_line” contain best-fitting parameters of our model for each cell-line, and variables SF_opt_”cell_line” contain best-fitting LQ surviving fractions.

data_iodine.mat
This workspace contains the sets of parameters used to create figures 2 and 3 (par_1, par_2, par_3, par_4). The variable D contains the simulated dose rate of a radioiodine treatment.

Experiment data files

Latest version

  • Version 1

    2020-01-30

    Published: 2020-01-30

    DOI: 10.17632/j3cy26nn8s.1

    Cite this dataset

    Neira, Sara; Gago-Arias, Araceli; Guiu-Souto, Jacobo; Pardo Montero, Juan (2020), “Data and code for "A kinetic model of continuous radiation damage to populations of cells: Comparison to the LQ model and application to molecular radiotherapy"”, Mendeley Data, v1 http://dx.doi.org/10.17632/j3cy26nn8s.1

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Categories

Mathematical Modeling, Medical Physics, Cancer Radiotherapy

Licence

CC BY 4.0 Learn more

The files associated with this dataset are licensed under a Creative Commons Attribution 4.0 International licence.

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