Data for: An Okadaic Acid Fragment Analogue Prevents Nicotine-Induced Resistance to Cisplatin by Recovering PP2A Activity in Non-Small Cell Lung Cancer Cells

Published: 28 April 2020| Version 1 | DOI: 10.17632/j64vt8hg95.1
de los Ríos Cristóbal, Judit Domenech Omella, Jose Luis Cedillo, Carmen Montiel, Veerle Janssens, Raquel L Arribas, Anna Bordas


Experiments represented in Fig. 2 are the molecular docking of ITH12680 with PP2A enzyme (Computational Medicinal Chemistry) Experiments represented in Fig. 3 are the PP2A activity in presence of ITH12680 and its selective inhibitor okadaic acid (protein serine-threonine phosphatase) Experiments represented in Fig. 4 show the effect of ITH12680 on the cell viability of A549 NSLC cells, compared with fingolimod (Cytotoxicity) Experiments represented in Fig. 5 show the apoptotic capacity of cisplatin on A549 NSLC cells, compromised by nicotine, in presence or abscence of ITH12680 (apoptosis) Experiments represented in Fig. 6 show the regulation of survival and proapoptotic phosphoproteins mediated by PP2A reactivation (Western-blot) Experiments represented in Fig. 7 show the effect of ITH12680 in the PP2A endogenous inhibitors expression (Western-blot)



Computational Medicinal Chemistry, Apoptosis, Cytotoxicity, Protein Serine-Threonine Phosphatase, Western Blot