Frontiers in Cell and Developmental Biology_Otis et al. 2024_Data raw
Description
The hypothesis of this preliminary study was that neuroepigenetics might be modulated by somatosensory sensitization development (or vice-versa) in an animal model of chronic OA pain. Taken together, the expression of neuroepigenetics, neuropeptidomics, and pain phenotype, particularly QST, would highlight pathophysiological mechanisms at the peripheral, spinal, and/or supraspinal levels, recognized to be involved in nociplastic pain. In a prospective, randomized, blinded, and controlled study, the objectives were to document parallel changes induced in the MI-RAT OA model on spinal neuroepigenetics and neuropeptidomics in the non-evoked expression of musculoskeletal pain, as well as on evoked QST. This would pursue the determination of the MI-RAT as a predictive and concurrently validated translatable OA model.