Destruction of self-derived PAMP via T3SS2 effector VopY to subvert PAMP-triggered immunity mediates Vibrio parahaemolyticus pathogenicity

Published: 18 October 2023| Version 1 | DOI: 10.17632/j9nk8rhbry.1
Xuan Wu, Lantian Zhou, Chen Ye, Zhenzhong Zha, Chuchu Li, Chao Feng, Yue Zhang, Qian Jin, Jianyi Pan


These data taken together demonstrate that VopY is a T3SS2 effector of Vibrio parahaemolyticus that confers both enterotoxicity and cytotoxicity. As a EAL-domain containing phosphodiesterase capable of hydrolyzing c-di-GMP, VopY effectively suppresses STING-dependent immune responses triggered by c-di-GMP, which is produced by bacteria and hijacked by the host as a signal during bacterial infection.



Pathogenic Microbes, Host-Pathogen Interaction