Serum albumin and white matter hyperintensities

Published: 31 May 2024| Version 1 | DOI: 10.17632/jcddr6tvj2.1
Natalie Zahr


Data used in manuscript: DOI : 10.1038/s41398-024-02953-5 Published in Translational Psychiatry


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Cross-sectional neuroimaging and clinical laboratory data were extracted from a longitudinal dataset drawn from published studies. Participants were recruited from local alcohol and drug recovery centers, HIV clinics, postcard mailings, recruitment flyers, and word of mouth. After obtaining written informed consent for study participation, approved by the SRI International and Stanford University School of Medicine Institutional Review Boards, volunteers underwent a Structured Clinical Interview for Diagnostic and Statistical Manual (DSM)-IV and DSM-5 Disorders (SCID), structured health questionnaires, and a semi-structured timeline follow-back interview to quantify lifetime alcohol consumption. FLAIR (FLuid-Attenuated Inversion Recovery) imaging was used for estimates of white matter hyperintensity (WMH) volumes WMH analysis was accomplished with the "UBO Detector". Blood samples were collected for analysis by Quest Diagnostics for complete blood count (CBC) (test: 6399, CPT: 85025), comprehensive metabolic panel (test code 10231, CPT code 80053), and HIV and HCV screening with RNA quantification for seropositive individuals.


Magnetic Resonance Imaging of Brain, Laboratory Value