Closed-Loop AUtomated Drug Infusion regulAtor (CLAUDIA): a clinically translatable, closed-loop drug delivery system

Published: 25 April 2024| Version 1 | DOI: 10.17632/jgf6m7x8nb.1
Contributors:
Louis DeRidder, Kyle Hare, Aaron Lopes, Josh Jenkins, Nina Fitzgerald, Emmeline MacPherson, Niora Fabian, Joshua Morimoto, Jacqueline N. Chu, Ameya Kirtane, Wiam Madani, Keiko Ishida, Johannes Kuosmanen, Naomi Zecharias, Christopher Colangelo, Hen-Wei Huang, Makaya Chilekwa, Nikhil Lal, Shriya Srinivasan, Alison Hayward, Brian Wolpin, David Trumper, Troy Quast, Douglas Rubinson, Robert Langer, Giovanni Traverso

Description

Data and code used in the publication in the journal "Med" titled: "Closed-Loop AUtomated Drug Infusion regulAtor: a clinically translatable, closed-loop drug delivery system" (doi.org/10.1016/j.medj.2024.03.020). The code includes: SIMULINK model of the system used in controller development (adapted from Mage, P., Ferguson, B., Maliniak, D. et al. Closed-loop control of circulating drug levels in live animals. Nat Biomed Eng 1, 0070 (2017). https://doi.org/10.1038/s41551-017-0070), Python code to implement the controller, Python code for data analysis and figure creation, and the TreeAge software used for the cost effectiveness analysis. We also upload the datafiles for the data used to create the figures in the manuscript.

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Institutions

Brigham and Women's Hospital, Massachusetts Institute of Technology, Dana Farber Cancer Institute, University of South Florida

Categories

Oncology, Data Analysis, Biological Control

Funders

  • Karl van Tassel Career Professorship MIT, the Department of Mechanical Engineering, MIT
  • Bridge Project, a partnership between the Koch Institute for Integrative Cancer Research at MIT and the Dana-Farber/Harvard Cancer Center
  • MathWorks Fellowship

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