Data of Baicalin

Published: 30 Jun 2020 | Version 3 | DOI: 10.17632/jm3fjvjyf2.3
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Description of this data

Results

  1. Effects of Baicalin on cell viability and LDH production
    Note:
    RAW264.7 cells viability——RAW细菌感染细胞活性
    H9 cells viability——H9细菌感染细胞活性
    1——control group;2——S. typhimurium group;3,4,5——S. typhimurium + Baicalin (25, 50, 100 μmol/L) group; 6——100 μmol/L Baicalin group

Note:
LDH of RAW264 cells——LDHRAW264
LDH of H9 cells cells——LDHH9
1——control group;2——S. typhimurium group;3,4,5——S. typhimurium + Baicalin (25, 50, 100 μmol/L) group; 6——100 μmol/L Baicalin group

  1. Effects of Baicalin on bactericidal effect
    Note:
    Bactericidal effect——rateofkilling
    1——S. typhimurium group;2,3,4——S. typhimurium + Baicalin (25, 50, 100 μmol/L) group.

  2. Effects of Baicalin on inflammatory cytokines and oxidative stress induced by S. typhimurium
    Note:
    The levels of TNF-α——TNFz;The levels of IL-1β——IL1z;The levels of IL-6——IL6z;The levels of IL-8——IL8z
    1——control group;2——S. typhimurium group;3,4,5——S. typhimurium + Baicalin (25, 50, 100 μmol/L) group; 6——100 μmol/L Baicalin group

ROS production——ROS
1——control group;2——S. typhimurium group;3,4,5——S. typhimurium + Baicalin (25, 50, 100 μmol/L) group; 6——100 μmol/L Baicalin group

  1. Baicalin mediated the autophagy and activation of TLR4 pathway induced by S. typhimurium
    Note:
    LC3 immuno-positive cells——荧光百分率
    1——control group;2——S. typhimurium group;3——S. typhimurium + Baicalin (100 μmol/L) group; 4——100 μmol/L Baicalin group

the expression of LC3-II/I——LC3;the expression of Beclin 1——Beclin 1
1——control group;2——S. typhimurium group;3——S. typhimurium + Baicalin (100 μmol/L) group; 4——100 μmol/L Baicalin group

the expression of TLR4, p-p38/p38, p-JNK/JNK, p-ERK/ERK——TLR4, p38, JNK, ERK
1——control group;2——S. typhimurium group;3——S. typhimurium + Baicalin (100 μmol/L) group; 4——100 μmol/L Baicalin group

  1. Effects of Baicalin on S. typhimurium-induced autophagy and activation of TLR4 pathway in TLR4 overexpression
    Note:
    the expression of TLR4——pcDNATLR4
    1——pcDNA3.1(+) group;2——pcDNA3.1-TLR4 group;

the expression of LC3, Beclin1, TLR4, p-p38/p38, p-JNK/JNK, p-ERK/ERK——LC32, Beclin12, TLR42, p382, JNK2, ERK2
1——pcDNA3.1(+)-S. typhimurium group;2——pcDNA3.1(+)-S. typhimurium + Baicalin group; 3—— pcDNA3.1-TLR4 -S. typhimurium group;4——pcDNA3.1-TLR4 -S. typhimurium + Baicalin group

Experiment data files

Latest version

  • Version 3

    2020-06-30

    Published: 2020-06-30

    DOI: 10.17632/jm3fjvjyf2.3

    Cite this dataset

    Ling, Zhang (2020), “Data of Baicalin ”, Mendeley Data, v3 http://dx.doi.org/10.17632/jm3fjvjyf2.3

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Jinzhou Medical University

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