Experimental Gerontology

Raw data for mitochondrial respiration and enzymatic activity experiments involving red blood cells from zebra finches.

Raw data set for "The effect of resistance training, detraining and retraining on muscle strength and power, myofibre size, satellite cells and myonuclei in older men". Corresponding author: martine.thomis@kuleuven.be

Patients and variables included in the research from which statistical analysis was carried out

Data set that corresponds with the manuscript, Evidence for premature aging in a Drosophila model of Werner syndrome

The file includes data for body composition, muscle function and muscle biopsy analyses

This database contains the main variables used in the analyses for the linked published manuscript.

Raw data from yeast replicative lifespan measurements

Raw data used in the publication: Crowding of Drosophila larvae affects lifespan and other life-history traits via reduced availability of dietary yeast Authors: Peter Klepsatel, Emanuel Procházka, Martina Gáliková Experimental Gerontology

Objectives: Changes of vasoconstriction may be measured non-invasively using pulse transit time. This study assessed the sensitivity, test-retest reliability and validity of pulse transit time during vasoconstriction provocation and active standing, and the predictive value of pulse transit time for blood pressure drop. Methods: Fifty-five younger (age < 65 years) and 31 older adults (age > 70 years) underwent electrocardiography, wrist and finger photoplethysmography and continuous blood pressure and total peripheral resistance measurements during vasoconstriction provocation using a cold pressor test (21 younger adults), or active stand tests (all other participants). Pulse transit time was defined as the time lag between the electrocardiography R-peak and the peak in the photoplethysmography first derivative; sensitivity as a significant decrease relative to baseline; test-retest reliability as the intra class correlation between different repeats of the same test; validity as the association between total peripheral resistance and pulse transit time; predictive value as the association between supine resting pulse transit time and mean arterial pressure drop during active standing. Results: Finger pulse transit time was sensitive and reliable (ICC 0.2-0.8) during vasoconstriction provocation, but wrist pulse transit time was poorly reliable (ICC 0 – 0.5); only finger pulse transit time was sensitive to and reliable (ICC 0.4 – 0.8) during active standing in both younger and older adults. Finger pulse transit time was not associated with total peripheral resistance. Supine resting pulse transit time had predictive value for blood pressure drop during active standing in older adults (β -0.16; p 0.025). Conclusions: Pulse transit time was sensitive to and reliable during vasoconstriction provocation and active standing, but did not significantly differ between younger and older adults. Pulse transit time could not be demonstrated to particularly reflect vasoconstriction, but it had predictive value for blood pressure drop during active standing.

Gene array data files compared gene expression profiles in liver samples from young (21-45 years) and old (69+ years) men and women to determine changes in the expression of xenobiotic metabolism enzymes and transporters. We identified genes that were differentially expressed in males only, females only, or in all individuals between the young and old using microarray.