Targeted proteomic analysis dataset of archival core human kidney biopsies to investigate the biology of hypertensive nephropathy.

Published: 11 November 2021| Version 1 | DOI: 10.17632/jv4ht2rvhx.1
Contributors:
Manousos Makridakis,
Georgios Barkas,
Harikleia Gakiopoulou,
Demetrios Vlahakos

Description

Hypertensive nephropathy is the second most frequent cause of end-stage renal disease in western societies. In previous experiments in our laboratory with proteomic analysis of renal parenchyma of SHR hypertensive animals, we identified two molecules, namely SGLT2 and CLIC4, associated with the development of hypertension. Targeted proteomic analysis was performed using the method: "Parallel Reaction Monitoring" (PRM) in renal parenchyma of hypertensive and normotensive patients for the selective identification of SGLT2 and CLIC4 and the relative quantification of their expression. Raw files of the targeted proteomics analysis of SGLT2 and CLIC4 in human kidney biopsies from hypertensive patients and normotensive controls are deposited in this dataset. Renal tissue biopsies (N = 13) from archival material of patients with hypertensive nephropathy (N=5, designated as HT) and normotensive controls (N=8, designated as C) were used. Our data show changes in the tubular compartment of the kidney and especially in the proximal tubules associated with the hypertensive nephropathy. The clinical significance of these findings should be further explored for the discovery and/or confirmation of novel therapeutic approaches and biomarkers in the development of hypertensive kidney disease.

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Proteomics

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