Comparative in vitro transportation of Pentamidine isethionate across BBB using polycaprolactone nanoparticles and liposomes

Published: 8 October 2018| Version 1 | DOI: 10.17632/k9b6dpyf76.1
Geofrey Omarch


This data informs on the capability of nanoparticles to transport pentamidine drug across the blood brain barrier. This data shows that polycaprolactone nanoparticles and liposomes were synthesized in nanoscale diameter, tested for cytotoxicity and thereafter assessed for their transport ability. Higher doses were toxic to cells. Test of safe doses showed that liposomes were able to comparatively transport efficiently pentamidine as compared to polycaprolactone nanoparticles. The quantities of pentamidine were anayzed using validated HPLC standards and drug was detected at 265 and 270 nm wavelengths in different media.



Nanoparticle Synthesis