The imaging profile of “probable PLS”: white and grey matter measures

Published: 01-08-2020| Version 2 | DOI: 10.17632/kbzmcydjzw.2
Peter Bede,
Eoin Finegan,
Kai Ming Chang,
Stacey Li Hi Shing,
Rangariroyashe H. Chipika,
Mary Clare McKenna,
Orla Hardiman


The recent consensus criteria for the diagnosis of primary lateral sclerosis (PLS) introduced the category of “probable PLS” for patients exhibiting upper-motor-neuron sings with a symptom duration interval of 2-4 years. These patients would have previously not met diagnostic criteria. In this dataset we present their imaging profile based on grey and white matter metrics in relevant anatomical regions in contrast to healthy controls and ‘definite PLS’ patients with over 4 years of symptom duration. The study was sponsored by the Spastic Paraplegia Foundation, Inc. (SPF), the Health Research Board (HRB EIA-2017-019), the EU Joint Programme – Neurodegenerative Disease Research (JPND), the Andrew Lydon scholarship, the Irish Institute of Clinical Neuroscience (IICN), the Iris O'Brien Foundation. Methodological details are provided in: Evolving diagnostic criteria in primary lateral sclerosis: The clinical and radiological basis of "probable PLS". Finegan E, Li Hi Shing S, Siah WF, Chipika RH, Chang KM, McKenna MC, Doherty MA, Hengeveld JC, Vajda A, Donaghy C, Hutchinson S, McLaughlin RL, Hardiman O, Bede P. J Neurol Sci. 2020 Jul 24;417:117052. doi: 10.1016/j.jns.2020.117052. Online ahead of print. PMID: 32731060