Published: 16 March 2023| Version 1 | DOI: 10.17632/kfkhgw359t.1
maria razzoli


These data refer to the survival and the healthspan of male mice of C57BL/6J, CD1, and Sv129Ev strain in response to lifelong chronic psychosocial stress (LCPS). Mice lifespan and healthspan were evaluated as a function of strain as well as of contextual aggressive behavior synthesized as a novel aggression index and indicative of coping style and social standing. DNA methylation data were analyzed in liver samples with the mouse DNA methylation array BeadChip by Illumina and all the raw data are deposited in NCBI Gene Expression Omnibus https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE216631 as described in the methods of the PNAS paper Razzoli et al., 2023 "Contextual modifiers of healthspan, lifespan and epigenome in mice under chronic social stress" and in the


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"km" are a files in wide format used for survival analysis and cox proportional hazard regression, one-way ANOVAs on variables such as aggression exhibited, received, and number of lesions, and multiple regression on baseline fat mass, fat free mass and aggression index. "healthspan" is a file in long format used to run linear mixed effect model analysis to study the effect of strain and discretized aggression index on each of the healthspan parameters (i.e., food intake, body weight, fat mass, fat free mass, plasma glucose). "percent mice presenting lesions" is a file containing the percentage of mice presenting each type of macroscopic lesion detected at necropsy, analyzed with chi-square tests for comparisons among groups as well as for binary comparisons. "weeks maintaining..." and "weeks to max'..." are files to analyze the time to maximum healthspan parameters values as well as time of duration of peak values (defined as values smaller than less than 1SD from the maximum value) among strains. "floating.bar" files are files capturing the time distribution and the percentage population of mice showing different lesions detectable at necrospy


University of Minnesota


Survival Analysis, Food Intake, Chronic Stress, Glucose, Aging, Territorial Aggression, Body Weight, Mouse Study, Lesion Studies, Mouse Stress Model, Consequence of Stress, Animal Body Composition