Interfacing of Near Point-of-Care Clinical Chemistry and Hematology Analyzers
Description
Supplementary file 1: Data for point-of-care testing on the Abaxis Piccolo Xpress device for basic metabolic panel (8 chemistry) and comprehensive metabolic panel (14 chemistry tests). Specimens analyzed were whole blood and include 4,219 specimens from 3,679 unique patients (2,287 female and 1,392 male). Specific data fields include sex (as recorded in the electronic medical record), age (in years), test panel, autoverification status (before electronic interface, result interfaced and autoverified, or result interfaced but some factor required manual entry of data), specific laboratory results, and anion gap. Supplementary file 2: Data for point-of-care testing on the Sysmex pocH-100i Automated Hematology Analyzer for complete blood count. Specimens analyzed were whole blood and include 4,342 specimens from 3,862 unique patients (2,371 female and 1,491 male). Specific data fields include sex (as recorded in the electronic medical record), age (in years), test panel, autoverification status (before electronic interface, result interfaced and autoverified, or result interfaced but some factor required manual entry of data), and specific laboratory results. Supplementary file 3: Data for central laboratory testing of the basic metabolic panel and comprehensive metabolic panel on Roche Diagnostic cobas 8000 analyzers and include 348,475 specimens from 124,810 unique patients (65,381 female and 59,429 male). Specimens analyzed were serum or plasma. Specific data fields include sex (as recorded in the electronic medical record), age (in years), test panel, specific laboratory results, and anion gap. All specimens were obtained at outpatient locations. Supplementary file 4: Combined data for anion gaps obtained from either point-of-care testing or central laboratory. The point-of-care data encompasses additional outpatient sites that utilized the Abaxis Piccolo Xpress device for running basic metabolic panel or comprehensive metabolic panel. There were a total of 361,199 specimens (12,724 point-of-care, 348,475 central laboratory) for which anion gap could be calculated. Specific data fields include testing source, [Na+], [HCO3-], [Cl-], and anion gap (all in units of mEq/L). All specimens were obtained at outpatient locations.
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The retrospective analysis period was July 1, 2017 to October 22, 2020. The project had approval from the University of Iowa Institutional Review Board. An electronic medical record (EMR) reporting program, known as Epic Reporting Workbench, was used to identify and retrieve data from the study as we have described in previous reports [1]. All data was for patient data in the EMR from the University of Iowa Hospitals and Clinics (Iowa City, Iowa, United States). No data was obtained from EMRs of other hospitals. Point-of-care (POC) testing was performed using Abaxis Piccolo Xpress and Sysmex pocH-100i Automated Hematology analyzers following manufacturer instructions. Central laboratory analysis of chemistry panels on serum/plasma specimens was performed on Roche Diagnostics cobas 8000 analyzers as previously described [2]. Calculated anion gap used the equation Anion Gap = [Na+] – [HCO3-] – [Cl-], with the electrolyte concentrations and anion gap in mEq/L [3]. References 1. Foster B, Krasowski MD: The Use of an Electronic Health Record Patient Portal to Access Diagnostic Test Results by Emergency Patients at an Academic Medical Center: Retrospective Study. J Med Internet Res 2019, 21(6):e13791. PMID: 31254335 2. Mainali S, Merrill AE, Krasowski MD: Frequency of icteric interference in clinical chemistry laboratory tests and causes of severe icterus. Pract Lab Med 2021, 27:e00259. PMID: 34761095 3. Kraut JA, Madias NE: Serum anion gap: its uses and limitations in clinical medicine. Clin J Am Soc Nephrol 2007, 2(1):162-174. PMID: 17699401