Data for: Dataset concerning plasmonic thermal destruction of murine melanoma by gold nanoparticles obtained by green chemistry.
Description
Data shown in this article provide information about the effect of photothermal therapy on an aggressive murine melanoma model. Mice were subcutaneously engrafted with B16F10 murine melanoma cells in the right flank. The treatment started when the tumor volume reached 120mm3 (Day 0). After the treatment, mice were weighed and the tumor volume was measured every 3 days until the death or the sacrifice of the mice (mice were euthanized if the tumor volume was higher than 1500mm3 or if the body weight loss was higher than 20%). Table 1 contains mice body weight (g) measured from the beginning (day 0=D0) of the treatment to its sacrifice (day 10=D10). The data were obtained from 25 melanoma bearing mice divided into 5 groups of mice: - Group 1: injection of nanoparticles without laser - Group 2: Laser exposure alone - Group 3/4: Nanoparticles combined with laser - Group 5: Reference treatment group (anti-PD1 monoclonal antibody). Throughout this experimentation, mice were weighed, and their clinical state was rigorously controlled. Table 2 describes the tumor mice dimensions of the 4 groups of mice (groups 1, 2, 3 & 5). The tumors are measured from the beginning of the treatment (D0) to its sacrifice (D10). For each mouse, the width, the length and the thickness of the tumor were measured with an electronic calliper (expressed in mm). Table 3 presents the estimated tumor volume of the 4 groups of mice. The estimated tumor volume is calculated from the tumor mice measurements. This volume was calculated with the following mathematical formula: Volume = (width x length x thickness) / 2, and was expressed in mm3. Table 4 contains the analysis of monitored weight and tumor volumes during the treatment from the groups of mice #3 and #5. Figure 1 illustrates the evolution of the relative median body weight (%) of 4 groups from D0 to D10 (groups #1, #2, #3, #5). Figure 2 illustrates the evolution of the median tumor volume of 4 groups from D0 to D10.